“Mechanically activated Piezo channels mediate touch and suppress acute mechanical pain response in mice”。


Highlights

  • Deletion of Piezo2 impairs touch but sensitizes mechanical pain in mice
  • Piezo1 expression can sensitize touch in normal mice and rescue defective touch of the Piezo2 deletion
  • Broad expression of Piezo1 in sensory neurons suppresses mechanical pain responses
  • Manipulating Piezo-mediated touch sensitivity affects pain sensitivity in mouse models